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Этанол
Повышение концентрации бензодиазепинов в плазме крови (конкуренция за микросомальные
ферменты; отсутствие действия или слабое действие при применении лоразепама, оксазепама и
темазепама)
Циметидин
Дисульфирам
Эритромицин
Эстрогены
Изониазид
СИОЗС
Снижение концентрации бензодиазепинов в плазме крови
Карбамазепин (возможно, и другие противоэпилептические препараты)
Литература
Фармакокинетика
Greenblatt DJ, Harmatz JS, Englehardt N, et al. Pharmacokinetic determinants of dynamic differences
among three benzodiazepine hypnotics. Arch Gen Psychiatry 1989; 46:326.
Greenblatt DJ, Shader RI, Koch-Weser J. Slow absorption of intramuscular chlordiazepoxide. N Engi J
Med 1974; 291:1116.
Saizman C, Shader RI, Greenblatt DJ, et al. Long vs. short half-life benzodiazepines in the elderly. Arch
Gen Psychiatry 1983; 40:293.
Scavone JM, Greenblatt DJ, Shader RI. Alprazolam kinetics following sublingual and oral
administration. J Clin Psychopharmacol 1987; 7:332.
Механизм действия
Levitan ES, Schofield PR, Burt DR, et al. Structural and functional basis for GABA
A
receptor
heterogeneity. Nature 1988; 335:76.
Pritchett DB, Sontheimer H, Shivers B, et al. Importance of a novel GABA
A
receptor subunit for
benzodiazepine pharmacology. Nature 1989; 338:582.
Показания
Тревога
Davidson JRT, Potts N, Richichi E, et al. Treatment of social phobia with clonazenam and placebo. J
Clin Psychopharmacol 1993; 13:423.
Kahn RJ, McNair DM, Lipman RS, et al. Imipramine and chlordiazepoxide in depressive and anxiety
disorders: II. Efficacy in anxious outpatients. Arch Gen Psychiatry 1986; 43:79.
Nagy LM, Krystal JH, Woods SW, et al. Clinical and medication outcome after short-term alprazolam
and behavioral group treatment in panic disorder. Arch Gen Psychiatry 1989; 46:993.
Rosenbaum JF, Moroz G, Bowden CL. Clonazepam in the treatment of panic disorder with or without
agoraphobia: a dose-response study of efficacy, safety, and discontinuance. J Clin Psychopharmacol
1997;
17:390.
Tesar GE, Rosenbaum JF, Pollack MH, et al. Double-blind, placebo-controlled comparison of
clonazepam and alprazolam for panic disorder. J Clin Psychiatry 1991; 52:69.
Депрессия
Lipman RS, Covi L, Rickels K, et al. Imipramine and chlordiazepoxide in depressive and anxiety
disorders: I. Efficacy in depressed outpatients. Arch Gen Psychiatry 1986; 43:68.
Rickels K, Chung HR, Csanalosi IB, et al. Alprazolam, diazepam, imipramine, and placebo in
outpatients with major depression. Arch Gen Psychiatry 1987; 44:862.
